Updated
Cholesterol and lipids
Shiitake, reishi, antrodia and oyster mushroom have been tried in people for this. The register's own words for this are hyperlipidemia, cholesterol, lipid, triglyceride.
Seven registered trials have looked at this, and 3 of them reported.
Species by species
| Species | How far it has got | Trials | With a result | Randomised | Commonly taken for it |
|---|---|---|---|---|---|
| Shiitake Lentinula edodes | Repeated trials | 3 | 1 | 1 | yes |
| Reishi Ganoderma lucidum | Repeated trials | 1 | 0 | 2 | — |
| Antrodia Taiwanofungus camphoratus | A first trial | 2 | 2 | 0 | — |
| Oyster mushroom Pleurotus ostreatus | A first trial | 1 | 0 | 1 | yes |
| Button mushroom Agaricus bisporus | A first trial | 0 | 0 | 1 | yes |
| Enoki Flammulina velutipes | Laboratory work | 0 | 0 | 0 | yes |
| King oyster Pleurotus eryngii | Laboratory work | 0 | 0 | 0 | yes |
| Maitake Grifola frondosa | Laboratory work | 0 | 0 | 0 | yes |
| Wood ear Auricularia auricula-judae | Laboratory work | 0 | 0 | 0 | yes |
Commonly taken for cholesterol and lipids, with the work still in the laboratory rather than in people: Button mushroom, Enoki, King oyster, Maitake, Wood ear.
The trials themselves
Every registered study that names one of these species and a condition the register files under this heading.
| Register | Study | Condition | People | Status | Result posted | Dose in the protocol |
|---|---|---|---|---|---|---|
| NCT02719028 | Trial of Antroquinonol in Patients With Hypercholesterolemia and Hyperlipidemia | Hyperlipidemias | 120 | Completed | yes | 50 mg |
| NCT04186780 | Effects of Lentinula Edodes Bars on Dyslipidemia and Oxidative Stress in Cholesterol Individuals: Randomized S | Dyslipidemias | 68 | Completed | yes | — |
| NCT01007656 | A Multiple-Dose Research Study on Safety Evaluation of the GD Antrodia Camphorata in 30 Healthy Adult Subjects | Healthy | 31 | Completed | yes | 500mg |
| NCT07534241 | Hepatoprotective Effects of Reishi Mushroom- (Ganoderma Lucidum) Among Metabolic Dysfunction-associated Fatty | Lipid Profile, Liver Biomarkers | 102 | Recruiting | — | 250 mg |
| NCT03550287 | Evaluation of the Effect of a Shiitake Extract on Lipid Profile in Subjects With Moderate Hyperlipidemia | Hypercholesterolemia, Hyperlipidemias | 57 | Completed | — | 10 g/day |
| NCT00069524 | Antihyperlipidemic Effects of Oyster Mushrooms | HIV Infections, Hyperlipidemia | 20 | Completed | — | — |
| NCT05619952 | Postprandial Lipemia and Glycemia Following a High-Fat Meal | Hypercholesterolemia, Postprandial Hyperglycemia | 16 | Completed | — | — |
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