Updated
Antrodia
A rare orange bracket found only on the endemic Taiwanese camphor tree, protected in the wild. Its compound antroquinonol reached registered oncology trials.
Repeated trials
Where it stands: 16 registered trials in people, six of which have reported; 4 randomised trials published since 2014.
What it is taken for
One tile per use. The line under each is how far the evidence for that use actually got, counted rather than argued.
What it has been tried for, and how far that has got
One row per use. The label is counted rather than argued — it is set by how many randomised trials and posted results exist for that use, and nothing else. How that is worked out.
| Use | How far it has got | Trials | With a result | Randomised, published | Reviews | Commonly taken for it |
|---|---|---|---|---|---|---|
| Cancer, supportive and adjuvant | Repeated trials | 6 | 3 | 2 | 0 | yes |
| Cholesterol and lipids | A first trial | 2 | 2 | 0 | 0 | — |
| Viral infection | A first trial | 1 | 1 | 0 | 0 | — |
| Liver | A first trial | 1 | 0 | 1 | 0 | yes |
| Skin | Being tested now | 2 | 0 | 0 | 0 | — |
| Fatigue and energy | Being tested now | 1 | 0 | 0 | 0 | yes |
| Sleep | Being tested now | 1 | 0 | 0 | 0 | — |
The doses the protocols actually specify
Taken verbatim from the intervention description each trial filed. These are not recommendations and they are not comparable to each other: some are a whole-mushroom powder, some a purified fraction.
Every registered study that names it
From ClinicalTrials.gov, filtered to studies that name Taiwanofungus camphoratus or a synonym in the title, summary or intervention. Studies that have posted results come first.
| Register | Study | Condition | People | Status | Result posted | Dose in the protocol |
|---|---|---|---|---|---|---|
| NCT01007656 | A Multiple-Dose Research Study on Safety Evaluation of the GD Antrodia Camphorata in 30 Healthy Adult Subjects | Healthy | 31 | Completed | yes | 500mg |
| NCT02047344 | Efficacy, Safety and Pharmacokinetics Study of Antroquinonol to Treat NSCLC | Non-small Cell Lung Cancer Stage IV | 31 | Completed | yes | 200 mg |
| NCT01134016 | Determine MTD and to Evaluate pk, Safety/Tolerability and Efficacy Profiles of Hocena® in NSCLC Subjects | Non-small Cell Lung Cancer | 13 | Completed | yes | 450, 600 mg/day, 50 mg |
| NCT03310632 | Determine Function of Antroquinonol in Combination With SOC in First Line Metastatic Pancreatic Cancer | Pancreatic Neoplasm | 55 | Completed | yes | — |
| NCT04523181 | Double-blind Study to Evaluate the Safety and Efficacy of Antroquinonol in Mild-Moderate COVID-19 Hospitalized | Covid-19 | 124 | Completed | yes | — |
| NCT02719028 | Trial of Antroquinonol in Patients With Hypercholesterolemia and Hyperlipidemia | Hyperlipidemias | 120 | Completed | yes | 50 mg |
| NCT07178093 | Effects of Antrodia Cinnamomea on the Hepatoma Patients After Transcatheter Hepatic Artery Chemoembolization | Hepatocellular Carcinoma, Transarterial Chemoembolization | 23 | Terminated | — | 2 capsule |
| NCT01287286 | Cancers Treated With Combination of Antrodia Cinnamomea and Chemotherapy | Neoplasm, Functional Gastrointestinal Disorder | 64 | Unknown | — | — |
| NCT02532699 | Anti-hypertensive Effect of Mycelia of Antrodia Cinnamomea | Hypertension | 41 | Completed | — | 420 mg |
| NCT05728918 | Effectiveness of Antrodia Cinnamomea Mycelia on Improving Immune Response in Subhealth People | Fatigue Syndrome, Chronic, Cold | 25 | Completed | — | 600 mg/day |
| NCT06633003 | Effects of Oral Administration of Antrodia Cinnamomea Products for Clinical Symptoms in Spinocerebellar Ataxia | Spinocerebellar Ataxia | 60 | Recruiting | — | — |
| NCT07241182 | Antrodia Cinnamomea Extract Effects on Lung Cancer Patients' Quality of Life During Chemotherapy | Lung Cancer (Diagnosis) | 40 | Recruiting | — | — |
| NCT03823352 | Evaluate Efficacy and Safety/Tolerability Profiles of Antroquinonol in Acute Myeloid Leukemia (AML) Adult Pati | Leukemia, Myeloid, Acute | 12 | Completed | — | 100 mg, 200mg |
| NCT03622463 | A Trial of Antroquinonol in Patients With Atopic Dermatitis | Atopic Dermatitis | 14 | Completed | — | 50 mg |
| NCT03625102 | A Randomized, Double-Blind Trial of Antroquinonol in Patients With Chronic Hepatitis B | HBV | 60 | Completed | — | 50 mg |
| NCT04110873 | A Phase II, Placebo-controlled Trial Evaluating the Efficacy of Antroquinonol in Patients With Atopic Dermatit | Atopic Dermatitis | 14 | Terminated | — | 50mg, 50mg per day |
The compounds the research names
Formula and mass from PubChem. Naming a compound is not a claim that it does anything in a person.
C29H44O6
C24H38O4
In the kitchen
Intensely bitter.
Not a food. Sold as an extract, a powder or a capsule in Taiwan, where the wild fungus is protected and the supply is cultivated.
Where it has been recorded, and when it fruits
19 verified occurrence records with coordinates, from GBIF. This is where people have recorded it, which follows where recorders live as much as where the fungus grows — read the shape, not the ranking.
| Taiwan | 17 | |
| Canada | 1 |
Most records fall in Mar. Northern-hemisphere recorders dominate the dataset, so a southern population would not show here.
iNaturalist separately holds 4 research-grade observations of it.
What has been reported going wrong
No voluntary adverse-event report to the US Food and Drug Administration names a product by this name. That is an absence of reports, not a demonstration of safety: these are the products least likely to be reported on, because nobody is required to.
The newest randomised trials and reviews
Indexed in Europe PMC. Titles and journals only — follow the link to read the paper where the publisher allows it.
| Year | Study | Journal | Kind | Citations |
|---|---|---|---|---|
| 2023 | Hepatoprotective effect of <i>Antrodia Cinnamomea</i> mycelia extract in subhealth Japanese adults: a randomized, double | J Diet Suppl | Randomised trial | 2 |
| 2021 | Hepatoprotective Effect of <i>Antrodia cinnamomea</i> Mycelium in Patients with Nonalcoholic Steatohepatitis: A Randomiz | J Am Coll Nutr | Randomised trial | 8 |
| 2016 | A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for pat open access | BMC Complement Altern Med | Randomised trial | 28 |
| 2014 | Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer | Nutr Res | Randomised trial | 25 |